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Associate Professor
최준호 (Choe, Junho), Ph.D.
Chair of Department of Life Science
Deputy Center Leader of HY-IBB
CAMPUS 222, Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea DEPARTMENT Department of Life Science, College of Natural Sciences, Hanyang University ADDRESS Natural Science Building (Office; 607, Lab; 616) 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea OFFICE Natural Science Building (Office; 607, Lab; 616) TEL +82-2-2220-0966 MAIL jcho2711@hanyang.ac.kr
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- Career
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- Department of Life Science, College of Natural Sciences, Hanyang University
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- Hanyang Institute of Bioscience and Biotechnology, Hanyang University
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- Hanyang Institute of Advanced BioConvergence, Hanyang University
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- Research Institute for Natural Sciences, Hanyang University
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- Research Institute for Convergence of Basic Sciences, Hanyang University Seoul, Republic of Korea
- Education
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Ph.D. (2009-2013)
Dept. of Biotechnology, Korea University, Seoul, Korea, Majored in molecular biology (Advisor: Prof. Yoon Ki Kim)
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M.S. (2007-2009)
Dept. of Biotechnology, Korea University, Seoul, Korea, Majored in molecular and cellular biology (Advisor: Prof. Yoon Ki Kim)
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B.S. (2003-2007)
University of Sydney, NSW, Australia, Majored in biochemistry
- Professional Experiences & Employments
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Associate professor (2022.03 - current)
Dept. of Life Science, College of Natural Sciences,
Research Institute for Natural Sciences,
Hanyang University, Seoul, Republic of Korea
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Assistant professor (2019.03 - 2022.02)
Dept. of Life Science, College of Natural Sciences,
Research Institute for Natural Sciences,
Hanyang University, Seoul, Republic of Korea
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Postdoctoral Fellow (Advisor: Richard I. Gregory) (2014.07 - 2019.01)
Stem Cell Program, Division of Hematology/Oncology,
Boston Children's Hospital, Boston, MA, USA
Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
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Research Professor (Advisor: Prof. Yoon Ki Kim) (2013.11 - 2014.05)
School of Life Sciences and Biotechnology,
Korea University, Seoul, Korea
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Postdoctoral Fellow (Advisor: Prof. Yoon Ki Kim) (2013.03 - 2013.10)
School of Life Sciences and Biotechnology,
Korea University, Seoul, Korea
- Publications
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Selected Publications
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1. Junho Choe*, Shuibin Lin*, Wencai Zhang, Qi Liu, Longfei Wang, Julia Ramirez-Moya, Peng Du, Wantae Kim, Shaojun Tang, Piotr Sliz, Pilar Santisteban, Rani E. George, William G. Richards, Kwok-Kin Wong, Nicolas Locker, Frank J. Slack, and Richard I. Gregory (2018.09) mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature, 561(7724):556-560. (*: equally contributed).
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2. Shuibin Lin*, Junho Choe*, Peng Du, Robinson Triboulet, and Richard I. Gregory (2016.05) The m6A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol cell, 62(3):335-45. (*: equally contributed).
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3. Junho Choe*, Incheol Ryu*, Ok Hyun Park, Joori Park, Hana Cho, Jin Seon Yoo, Sung Wook Chi, Min Kyung Kim, Hyun Kyu Song, and Yoon Ki Kim (2014.10) eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5'UTR. Proc Natl Acad Sci U S A, 111(43):E4577-86. (*: equally contributed).
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4. Junho Choe, Sang Ho Ahn, and Yoon Ki Kim (2014.08) The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA. Nucleic Acids Res, 42(14): 9334-49.
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5. Junho Choe*, Kyoung Mi Kim*, Sungjin Park, Ye Kyung Lee, Ok-Kyu Song, Min Kyung Kim, Byung-Gil Lee, Hyun Kyu Song, and Yoon Ki Kim (2013.01) Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Res, 41(2):1307-18. (*: equally contributed).
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6. Junho Choe*, Nara Oh*, Sungjin Park, Ye Kyung Lee, Ok-Kyu Song, Nicolas Locker, Sung-Gil Chi, and Yoon Ki Kim (2012.05) Translation Initiation on mRNAs Bound by Nuclear Cap-binding Protein Complex CBP80/20 Requires Interaction between CBP80/20-dependent Translation Initiation Factor and Eukaryotic Translation Initiation Factor 3g. J Biol Chem, 287(22):18500-9. (*: equally contributed).
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7. Junho Choe, Hana Cho, Sung-Gil Chi, Yoon Ki Kim (2011.09) Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2. FEBS Lett, 585(17):2682-7.
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8. Junho Choe, Hana Cho, Hyung Chul Lee, and Yoon Ki Kim. (2010.05) microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay. EMBO Rep, 11(5):380-6.
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Other Publications
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1. Jasmin Paris, Marcos Morgan, Joana Campos, Gary J. Spencer, Alena Shmakova, Ivayla Ivanova, Christopher Mapperley, Hannah Lawson, David A. Wotherspoon, Catarina Sepulveda, Milica Vukovic, Lewis Allen, Annika Sarapuu, Andrea Tavosanis, Amelie V. Guitart, Arnaud Villacreces, Christian Much, Junho Choe, Ali Azar, Louie N. van de Lagemaat, Douglas Vernimmen, Ali Nehme, Frederic Mazurier, Tim C.P. Somervaille, Richard I. Gregory, Do´ nal O’Carroll#, and Kamil R. Kranc# (2019.07) Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell, 25(1):137-148.e6. (#: co-corresponding author).
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2. Mehdi Pirouz, Marzia Munafò, Aref G. Ebrahimi, Junho Choe, and Richard I. Gregory* (2019.06) Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance. Nat Struct Mol Biol, 26(6):490-500.
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3. Incheol Ryu*, You-Sub Won*, Hongseok Ha, Eunjin Kim, Yeonkyoung, Park, Min Kyung Kim, Do Hoon Kwon, Junho Choe, Hyun Kyu Song, Hosung Jung, and Yoon Ki Kim (2019.02) eIF4A3 phosphorylation by CDKs affects NMD during the cell cycle. Cell Reports, 26(8):2126-2139.e9. (*: equally contributed).
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4. Shuibin Lin*, Qi Liu*, Victor S. Lelyveld, Junho Choe, Jack W. Szostak, and Richard I. Gregory (2018.07) Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol cell, 71(2):244-255.e5. (*: equally contributed).
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5. Joori Park*, Yeonkyoung Park*, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, and Yoon Ki Kim (2017.06) Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex. Nat Commun, 8:15730. (*: equally contributed).
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6. Partha Pratim Das, David A. Hendrix, Effie Apostolou, Alice H. Buchner, Matthew C. Canver, Semir Beyaz, Damir Ljuboja, Rachael Kuintzle, Woojin Kim, Rahul Karnik, Zhen Shao, Huafeng Xie, Jian Xu, Alejandro De Los Angeles, Yingying Zhang, Junho Choe, Don Leong Jia Jun, Xiaohua Shen, Richard I. Gregory, George Q. Daley, Alexander Meissner, Manolis Kellis, Konrad Hochedlinger, Jonghwan Kim, and Stuart H. Orkin (2015.09) PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep, 12(9):1456-70.
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7. KY Kim, YJ Hwang, M-K Jung, J Choe, Y Kim, S Kim, C-J Lee, H Ahn, J Lee, NW Kowall, YK Kim, J-I Kim, SB Lee, and H Ryu (2014.01) A multifunctional protein EWS regulates the expression of Drosha and microRNAs. Cell Death and Differ, 21(1):136-45.
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8. Hana Cho, Sisu Han, Junho Choe, Seung Gu Park, Sun Shim Choi, and Yoon Ki Kim (2013.01) SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay. Nucleic Acids Res, 41(2):1319-28.
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9. Jun Cho, Hyeshik Chang, S. Chul Kwon, Baekgyu Kim, Yoosik Kim, Junho Choe, Minju Ha, Yoon Ki Kim, and V. Narry Kim (2012.11) LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells. Cell, 151(4):765-77.
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10. Hana Cho, Kyoung Mi Kim, Sisu Han, Junho Choe, Seung Gu Park, Sun Shim Choi, and Yoon Ki Kim (2012.05) Staufen1-Mediated mRNA Decay Functions in Adipogenesis. Mol Cell, 46(4):495-506.
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11. Hyung Chul Lee, Nara Oh, Hana Cho, Junho Choe, and Yoon Ki Kim (2010.02) Nonsense-mediated translational repression involves exon junction complex downstream of premature translation termination codon. FEBS Lett, 584(4):795-800.
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12. Hyung Chul Lee, Junho Choe, Sung-Gil Chi, and Yoon Ki Kim. (2009.07) Exon junction complex enhances translation of spliced mRNAs at multiple steps. Biochem Biophys Res Commun, 384(3):334-40.
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13. Nara Oh, Kyoung Mi Kim, Junho Choe, and Yoon Ki Kim (2007.10) Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia. FEBS Lett, 581(26):5158-64.
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14. Nara Oh, Kyoung Mi Kim, Hana Cho, Junho Choe, and Yoon Ki Kim (2007.10) Pioneer round of translation occurs during serum starvation. Biochem Biophys Res Commun, 362(1):145-51.
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